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Annual Reviews по журналам "Annual Review of Pathology: Mechanisms of Disease"

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  • Karnovsky Morris J. (Annual Reviews, 2006-02-01)
    I am honored to write the prefatory chapter for the inaugural volume of the Annual Review of Pathology: Mechanisms of Disease. This publishing venture signals that pathology takes its rightful place alongside ...
  • Dong Zheng; Saikumar Pothana; Weinberg Joel M.; Venkatachalam Manjeri A. (Annual Reviews, 2006-02-01)
    Abstract Loss of Ca2+ homeostasis, often in the form of cytoplasmic increases, leads to cell injury. Depending upon cell type and the intensity of Ca2+ toxicity, the ensuing pathology can be reversible or irreversible. ...
  • Srivastava Deepak (Annual Reviews, 2006-02-01)
    Abstract Developmental heart disorders are the most common of all human birth defects and occur in nearly one percent of the population. Survivors of congenital heart malformations are an increasing population, and it is ...
  • Rijn Matt van de; Fletcher Jonathan A. (Annual Reviews, 2006-02-01)
    Abstract Sarcomas form a highly diverse group of rare tumors that are derived from connective tissue. More than 100 different malignant and benign soft tissue neoplasms can be recognized by histologic examination. Few ...
  • Guidotti Luca G.; Chisari Francis V. (Annual Reviews, 2006-02-01)
    Abstract Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV) and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause persistent infection, cirrhosis, and ...
  • Hansson Göran K.; Robertson Anna-Karin L.; Söderberg-Nauclér Cecilia (Annual Reviews, 2006-02-01)
    Abstract Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing low-density lipoproteins accumulate ...
  • Tomlins Scott A.; Rubin Mark A.; Chinnaiyan Arul M. (Annual Reviews, 2006-02-01)
    Abstract Prostate cancer displays considerable clinical, morphological, and biological heterogeneity. Classical genetic techniques have provided only limited information about the pathogenesis of prostate cancer progression. ...
  • Ganem Don (Annual Reviews, 2006-02-01)
    Abstract Kaposi's sarcoma (KS) has long been suspected of having an infectious etiology on the basis of its unusual epidemiology, histopathology, and natural history. Nearly a decade ago, a novel herpesviral genome was ...
  • Wistuba Ignacio I.; Gazdar Adi F. (Annual Reviews, 2006-02-01)
    Abstract From histological and biological perspectives, lung cancer is a complex neoplasm. Although the sequential preneoplastic changes have been defined for centrally arising squamous carcinomas of the lung, they have ...
  • Louis David N. (Annual Reviews, 2006-02-01)
    Abstract Malignant gliomas, the most common type of primary brain tumor, are a spectrum of tumors of varying differentiation and malignancy grades. These tumors may arise from neural stem cells and appear to contain tumor ...
  • Skovronsky Daniel M.; Lee Virginia M.-Y.; Trojanowski John Q. (Annual Reviews, 2006-02-01)
    Abstract Neurodegenerative diseases as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposition of misfolded proteins, which leads to ...
  • Kwoh Christopher; Shannon M. Brendan; Miner Jeffrey H.; Shaw Andrey (Annual Reviews, 2006-02-01)
    Abstract Nonimmune glomerulopathies are an area of significant research. This review discusses the development of focal segmental glomerulosclerosis, with particular attention to the role of the podocyte in the initiation ...
  • Неизвестный автор (Annual Reviews, 2006-02-01)
  • McKerrow James H.; Caffrey Conor; Kelly Ben; Loke P'ng; Sajid Mohammed (Annual Reviews, 2006-02-01)
    Abstract Parasitic diseases represent major global health problems of immense proportion. Schistosomiasis, malaria, leishmaniasis, Chagas disease, and African sleeping sickness affect hundreds of millions of people worldwide, ...
  • Gao Hongwei; Neff Thomas; Ward Peter A. (Annual Reviews, 2006-02-01)
    Abstract Modern techniques of cell and molecular biology have rapidly uncovered the mechanisms underlying inflammatory injury of the lung. This expanding knowledge (which includes an understanding of complement, cell surface ...
  • Munford Robert S. (Annual Reviews, 2006-02-01)
    Abstract Although Gram-negative bacteria have often been implicated in the pathogenesis of severe sepsis and septic shock, how they trigger these often lethal syndromes is uncertain. In particular, the role played by ...
  • Kutok J.L.; Wang F. (Annual Reviews, 2006-02-01)
    Abstract The association between Epstein-Barr virus (EBV) and a large number of benign and malignant diseases is unique among DNA viruses. Within infected tissues, proteins that are expressed during the normal lytic and ...
  • Valbuena Gustavo; Walker David H. (Annual Reviews, 2006-02-01)
    Abstract The endothelial cells lining vascular and lymphatic vessels are targets of several infectious agents, including viruses and bacteria, that lead to dramatic changes in their functions. Understanding the pathophysiological ...
  • Atherton John C. (Annual Reviews, 2006-02-01)
    Abstract Helicobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma, and gastric lymphoma. Only 15% of those colonized develop disease, and pathogenesis depends upon strain virulence, host ...
  • Tlsty Thea D.; Coussens Lisa M. (Annual Reviews, 2006-02-01)
    Abstract In the past 25 years, a majority of cancer studies have focused on examining functional consequences of activating and/or inactivating mutations in critical genes implicated in cell cycle control. These studies ...