Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage Ï X 174 in vitro
TAO, TIEN-WEN; LEARY, PATRICIA L.
Журнал:
Nature
Дата:
1969
Аннотация:
WHOLE body X-irradiation depresses or enhances the antibody response depending on the dosage and its temporal relationship to injection of antigen in the animal<sup>1</sup>. Using organ cultures of rabbit lymph nodes, we succeeded in initiating both primary and secondary types of antibody response to bacteriophage Ï X 174 in vitro<sup>2,3</sup>. The experiments reported here (a) test this in vitro system for its use in the study of radiation effects on the antibody response, (b) further elucidate the mechanisms of radiation-induced enhancement of the primary antibody response, and (c) compare radiosensitivity of primary and secondary responses initiated in the cultures.
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