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Royal Society of Chemistry по журналам "Accounts in Drug Discovery"

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  • Robl Jeffrey A.; Hamann Lawrence G. (The Royal Society of Chemistry, 2011)
    Utilizing modern principles of rational drug design originally pioneered by Miguel Ondetti and David Cushman in the discovery of captopril, the team at BristolMyers Squibb discovered saxagliptin Onglyza, a smallmolecule ...
  • Mackman Richard (The Royal Society of Chemistry, 2011)
    First line therapy for treatmentnave HIV patients typically include the combination of two drugs from the nucleoside or nucleotide class NtRTIs, that target the viral reverse transcriptase RT, along with either a nonnucleoside ...
  • Sofia Michael J.; Furman Phillip A.; Symonds William T. (The Royal Society of Chemistry, 2011)
    Hepatitis C virus HCV is believed to have infected over 170 million individuals worldwide and is considered a global health problem. Infection with HCV is known to lead to chronic liver disease, cirrhosis and eventually ...
  • Fish Paul V.; Harrison Anthony; Wakenhut Florian; Whitlock Gavin A. (The Royal Society of Chemistry, 2011)
    This chapter describes the case history of a drug discovery project targeting a centrally penetrant, dual serotoninnoradrenaline reuptake inhibitor SNRI for the treatment of stress urinary incontinence, and highlights how ...
  • Norman Mark H. (The Royal Society of Chemistry, 2011)
    The Transient Receptor Potential Vanilloid 1 TRPV1 ion channel was first cloned and characterized in late 1997 by Michael Caterina, David Julius and colleagues. In the decade that followed an explosion of research from ...
  • Graziani Edmund I. (The Royal Society of Chemistry, 2011)
    Natural product scaffolds are privileged structures that have withstood the pressures of eons of natural selection and have demonstrated utility in human medicine. They therefore represent a potential bridge to balancing ...
  • Rogers Bruce N.; Jon Jacobsen E.; ODonnell Christopher J.; Shaffer Christopher L.; Walker Daniel P.; Wishka Donn G. (The Royal Society of Chemistry, 2011)
    The 7 nicotinic acetylcholine receptor nAChR has been a target of interest to the neuroscience area for the treatment of cognitive deficits in schizophrenia for some time. The pentameric 7 nAChR is the most abundant nAChR ...
  • Chackalamannil Samuel (The Royal Society of Chemistry, 2011)
    The coagulation and platelet activation mechanisms synergize in hemostasis and thrombosis. Thrombin plays a key dual role in these by generation of fibrin from fibrinogen and by activation of platelets via protease activated ...
  • Sarabu Ramakanth; Tilley Jefferson W.; Grimsby Joseph (The Royal Society of Chemistry, 2011)
    Glucokinase GK plays a key role in wholebody glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as pancreatic cells and hepatocytes. Glucokinase activators GKA represent ...
  • Mulvihill Mark J.; Buck Elizabeth (The Royal Society of Chemistry, 2011)
    The insulinlike growth factor1 and insulin receptors IGF1R and IR, respectively are closely related transmembrane receptor tyrosine kinases. Both receptors have been implicated in the promotion of growth and survival of ...
  • HamannFormerly at Pfizer, 401 N. Middletown Rd., Pearl River, NY 10965, USA. Philip R. (The Royal Society of Chemistry, 2011)
    Gemtuzumab ozogamicin is an antibody conjugate of calicheamicin that targets the CD33 antigen on differentiating myeloid cells and which is overexpressed on acute myeloid leukemia cells in most patients. It carries a ...
  • Gavai Ashvinikumar V.; Foster William R.; Balog Aaron; Vite Gregory D. (The Royal Society of Chemistry, 2011)
    The etiology and progression of prostate cancer is dependent on androgens and their signaling, which is mediated by the androgen receptor AR. Standard treatment for prostate carcinoma involves androgen depletion with ...
  • Andrews Mark D.; Middleton Donald S. (The Royal Society of Chemistry, 2011)
    With the realisation that selective serotonin reuptake inhibitors SSRIs are effective in treating premature ejaculation PE, a project was started to identify a short T12, rapid Tmax compound suitable for ondemand dosing. ...
  • Bell Andrew S.; Palmer Michael J. (The Royal Society of Chemistry, 2011)
    Clinical studies with our male erectile dysfunction medicine, sildenafil, identified several additional indications for PDE5 inhibitors. Since these include disease indications requiring chronic treatment andor single dose ...
  • Barber Chris; Pryde David (The Royal Society of Chemistry, 2011)
    AIDS has claimed the lives of over 25 million people, driving the continuing desire to identify new treatments for this devastating disease. Maraviroc, the first CC Chemokine Receptor 5 CCR5 antagonist to be licensed as a ...
  • Barrish Joel C.; Carter Percy H.; Cheng Peter T. W.; Zahler Robert (The Royal Society of Chemistry, 2011)
  • Barrish Joel C.; Carter Percy H.; Cheng Peter T. W.; Zahler Robert (The Royal Society of Chemistry, 2011)
  • Barrish Joel C.; Carter Percy H.; Cheng Peter T. W.; Zahler Robert (The Royal Society of Chemistry, 2011)
  • Barrish Joel C.; Carter Percy H.; Cheng Peter T. W.; Zahler Robert (The Royal Society of Chemistry, 2011)
  • Barrish Joel C.; Carter Percy H.; Cheng Peter T. W.; Zahler Robert (The Royal Society of Chemistry, 2011)