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  • MARSHALL EDWARD H. (Oxford University Press, 1895-07-01)
  • MARSHALL JULIAN (Oxford University Press, 1889-05-01)
  • THOMAS N. W. (Oxford University Press, 1915-12-01)
  • HALL HAMMOND (Oxford University Press, 1903-01-01)
  • Bates Stewart; Phillips Andrew C.; Clark Paula A.; Stott Francesca; Peters Gordon; Ludwig Robert L.; Vousden Karen H. (Macmillan Magazines Ltd., 1998-09-01)
    Most human cancers show perturbation of growth regulation mediated by the tumour-suppressor proteins retinoblastoma (RB) and p53 (ref. 1), indicating that loss of both pathways is necessary for tumour development. Loss of ...
  • Krimpenfort Paul; IJpenberg Annemieke; Song Ji-Ying; van der Valk Martin; Nawijn Martijn; Zevenhoven John; Berns Anton (Nature Publishing Group, 2007-08-01)
    The CDKN2b–CDKN2a locus on chromosome 9p21 in human (chromosome 4 in mouse) is frequently lost in cancer. The locus encodes three cell cycle inhibitory proteins: p15INK4b encoded by CDKN2b, p16INK4a encoded by CDKN2a and ...
  • Ivinson Adrian J. (1994-09-01)
  • Spruck Charles H.; Gonzalez-Zulueta Mirella; Shibata Atsuko; Simoneau Anne R.; Lin Ming-Fong; Gonzales Felicidad; Tsai Yvonne C.; Jones Peter A. (1994-07-01)
  • Krishnamurthy Janakiraman; Ramsey Matthew R.; Ligon Keith L.; Torrice Chad; Koh Angela; Bonner-Weir Susan; Sharpless Norman E. (Nature Publishing Group, 2006-09-01)
    The p16INK4a tumour suppressor accumulates in many tissues as a function of advancing age. p16INK4a is an effector of senescence and a potent inhibitor of the proliferative kinase Cdk4 (ref. 6), which is essential for ...
  • Shigemasa K.; Hu C.; West C. M.; Clarke J.; Pharham G. P.; Parmley T. H.; Korourian S.; Baker V. V.; O'Brien T. J. (Sage Publications, 1997)
    Objective:The recently cloned gene p16 (MST 1) has been identified as a putative tumor suppressor gene that binds to CDK4 and CDK6 (cyclin-dependent kinases), preventing their interaction with cyclin D1 and thereby preventing ...
  • Qi Ying; Gregory Mark A.; Li Zhaoliang; Brousal Jeffrey P.; West Kimberly; Hann Stephen R. (Macmillian Magazines Ltd., 2004-09-01)
    Increased expression of the oncogenic transcription factor c-Myc causes unregulated cell cycle progression. c-Myc can also cause apoptosis, but it is not known whether the activation and/or repression of c-Myc target genes ...
  • Palmero Ignacio; Pantoja Cristina; Serrano Manuel (Macmillan Magazines Ltd., 1998-09-01)
    Normal healthy cells possess safeguard mechanisms that sense oncogenic signals and trigger anti-tumorigenic responses that limit the proliferative potential of cells harbouring active oncogenes. In particular, expression ...
  • IKIN ELIZABETH; KAY H. E. M.; PLAYFAIR J. H. L.; MOURANT A. E. (1961-12-01)
    IT is well established that in the human fœtus and new-born the P1 antigen is incompletely expressed1,2. In the course of testing blood from 403 fœtuses between the ages of 12 and 28 weeks we have confirmed that the incidence ...
  • Tomasz J. (Taylor & Francis Group, 1983-01-01)
    The title compound 1 is prepared from thymidine 5′-phos-phorodiamidate (2) and inorganic pyrophosphate (3) in anhydrous DMF, at 30–32°C. The products of alkaline hydrolysis of 1, at room temperature, are: thymidine ...
  • Неизвестный автор (Oxford University Press, 1995-05-01)
  • Pines Jonathon (1994-06-01)
  • Xiong Yue; Hannon Gregory J.; Zhang Hui; Casso David; Kobayashi Ryuji; Beach David (1993-12-01)
    DEREGULATION of cell proliferation is a hallmark of neoplastic transformation. Alteration in growth control pathways must translate into changes in the cell-cycle regulatory machinery, but the mechanism by which this occurs ...
  • Peyman Anusch (Oxford University Press, 1994-04-01)
    The function of the P2 stem-loop region in the group I catalytic intron from Tetrahymena thermophlla has been investigated. A comprehensive mutation analysis suggests that the bottom base pair of the P2 stem and nucleotides ...
  • Неизвестный автор (Oxford University Press, 1990)
  • Неизвестный автор (Oxford University Press, 1994-05-01)