| Автор | Rosenkranz, Herbert S. |
| Автор | Klopman, Gilles |
| Дата выпуска | 1990 |
| dc.description | A structure – activity study of 1-amino-2-naphthol derived azo dyes using CASE, the Computer Automated Structure Evaluation system, revealed that for optimal mutagenicity, reduction of the azo bond was required, thus suggesting that activity could be related to the liberated aromatic amines. Although it has long been known that sulfonation of azo dyes resulted in decreased carcinogenicity and mutagenicity, the present study elucidates the sites of sulfonation which will decrease mutagenicity maximally. Comparison of CASE predictions with available mutagenicity data indicates a concordance. Unexpectedly, CASE indicates that one of the aromatic amines obtained upon azoreduction of FD and C Red no. 40 is predicted to be mutagenic. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | ORIGINAL PAPERS |
| Название | Structural basis of the mutagenicity of 1-amino-2-naphthol-based azo dyes |
| Тип | research-article |
| Electronic ISSN | 1464-3804 |
| Print ISSN | 0267-8357 |
| Журнал | Mutagenesis |
| Том | 5 |
| Первая страница | 137 |
| Последняя страница | 146 |
| Аффилиация | Departments of Environmental Health Sciences and Chemistry, Case Western Reserve UniversityCleveland, OH 44106, USA |
| Выпуск | 2 |
