| Автор | Likhachev, Alexei J. |
| Автор | Warren, Harbour S. |
| Автор | Slaga, Thomas J. |
| Дата выпуска | 1992 |
| dc.description | The level of the DNA repair enzyme O<sup>6</sup>-alkylguanine-DNA alkyltransferase (MGMT) was examined in benign and malignant skin tumors induced with different initiating and promoting agents and from both SENCAR and Sensitive SENCAR Inbred (SSIN) mice. The MGMT levels in the tumors were approximately one-half the level observed in normal surrounding epidermis and in keratinocytes from untreated controls. In addition, a carcinoma-producing cell line, VT 17DT, derived from papillomas in SENCAR mice had no detectable MGMT activity (Mer- phenotype), whereas in the non-tumor forming line, 3PC, MGMT activity was comparable to that in papillomas. The comparatively low level of MGMT in papillomas may contribute to their ease of conversion to squamous cell carcinomas by N-ethyl-N-nhxosourea or n-methyl-N'-nitro-N-nitrosoguanidme. MGMT activity was also determined in the epidermis of non-exposed mice of various stocks and strains. Epidermal MGMT activity was similar to levels in the corresponding livers and was, in general, parallel with stock/strain susceptibility to tumor formation. This is the first report that examined MGMT activity in skin tumors and normal keratinocytes in the mice of several stocks and strains. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | SHORT COMMUNICATION |
| Название | 0<sup>6</sup>-Alkylguanine-DNA alkyltransferase activity in epidermal tumor and normal epidermal cells of mice of various stocks and strains |
| Тип | other |
| Electronic ISSN | 1460-2180 |
| Print ISSN | 0143-3334 |
| Журнал | Carcinogenesis |
| Том | 13 |
| Первая страница | 1265 |
| Последняя страница | 1268 |
| Аффилиация | N.N.Petrov Research Institute of OncologySt Petersburg, 189646, Russia |
| Аффилиация | Likhachev Alexei J.; Visiting scientist at University of Texas M.D.Anderson Cancer Centre |
| Аффилиация | Warren Harbour S.; University of Texas M.D.Anderson Cancer Center Science Park-Research Division |
| Аффилиация | Slaga Thomas J.; University of Texas M.D.Anderson Cancer Center Science Park-Research Division |
| Выпуск | 7 |
