| Автор | ISHIHARA, HIROAKI |
| Автор | HIGASHI, KIICHIRO |
| Автор | KENJI, ETO |
| Автор | SATO, TATSUO |
| Дата выпуска | 1978 |
| dc.description | This case study concerns a 56-year-old man who exhibited hypercalcemia due to T-cell leukemia. The leukemic cell was identified to be of T-cell origin by the method of routine T- and B-cell markers (E rosette and EAC rosette formation). Hypercalcemic crisis occurred in conjunction with an increase in leukemic cells. X-ray studies revealed no apparent skeletal bone destructions by metastasis of leukemic cells, but showed cortical erosion of the phalanges of the hands. Hypophosphatemia and decreased tubular reabsorption of phosphates were also observed. However, immunoreactive parathyroid hormone (iPTH) in his serum was not detected. The serum calcium concentration returned to its normal level in the coincidental improvement of the leukemia after responding to chemotherapy. In order to test whether the leukemic cells produce an active substance or not, studies were carried out in vitro, that is, culture mediums were obtained from leukemic cells incubated for 24 hours and injected into chicks, and their serum calcium concentrations were measured. Significant elevations in the calcium level were found when compared with controls. No iPTH was detectable in the culture medium. It was concluded that the hypercalcemia in this patient could be due to a humoral factor (or factors) other than iPTH, which was produced by T-leukemic cells. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Oxford University Press |
| Тема | Case Reports |
| Название | A Case of Adult T-cell Leukemia Associated With Hypercalcemia |
| Тип | case-report |
| Electronic ISSN | 1465-3621 |
| Print ISSN | 0368-2811 |
| Журнал | Japanese Journal of Clinical Oncology |
| Том | 8 |
| Первая страница | 187 |
| Последняя страница | 194 |
| Аффилиация | Department of Internal Medicine, University of Kumamoto School of MedicineKumamoto, Japan |
| Выпуск | 2 |
