| Автор | Reaven, Gerald M. |
| Дата выпуска | 1993 |
| dc.description | Resistance to insulin-mediated glucose uptake is characteristic of individuals with impaired glucose intolerance or non-insulin-dependent diabetes, and it also occurs commonliyn patients with high blood pressure. The physiological response to a decrease in insulin-mediated glucose uptake is an increase in insulin secretion, and as long as a state of compensatory hyperinsulinemia can be maintained, frank decompensation of glucose tolerance can be prevented. However, it is likely that the defect in insulin action and/or the associated hyperinsulinemia will lead to an increase in plasma triglyceride and a decrease in high density lipoprotein-cholesterol concentration, and high blood pressure. It seems likely that the cluster of changes associated with resistance to insulin-mediated glucose uptake comprise a syndrome, which plays an important role in the etiology and clinical course of patients with non-insulin-dependent diabetes, high blood pressure, and coronary heart disease. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition |
| DOI | 10.1146/annurev.me.44.020193.001005 |
| Print ISSN | 0066-4219 |
| Журнал | Annual Review of Medicine |
| Том | 44 |
| Первая страница | 121 |
| Последняя страница | 131 |
| Аффилиация | Reaven, Gerald M.; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305; and Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Palo Alto, California 94304 |
