| Автор | Wysolmerski, John J. |
| Автор | Broadus, Arthur E. |
| Дата выпуска | 1994 |
| dc.description | ▪ Abstract Hypercalcemia is the most common metabolic complication of cancer. Malignancy-associated hypercalcemia (MAHC) can be divided into two syndromes, humoral hypercalcemia of malignancy (HHM) and local osteolytic hypercalcemia (LOH), based on whether a circulating hormone or local paracrine factors mediate accelerated bone resorption. Over the past decade, studies have shown that parathyroid hormone-related protein is the cause of the HHM syndrome, and recent data suggest that this protein may also play a paracrine role in some patients with local osteolytic hypercalcemia. Study of the regulation of parathyroid hormone-related protein gene expression is beginning to shed some light on the molecular mechanisms responsible for this common clinical problem. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | HYPERCALCEMIA OF MALIGNANCY: The Central Role of Parathyroid Hormone-Related Protein |
| DOI | 10.1146/annurev.med.45.1.189 |
| Print ISSN | 0066-4219 |
| Журнал | Annual Review of Medicine |
| Том | 45 |
| Первая страница | 189 |
| Последняя страница | 200 |
| Аффилиация | Wysolmerski, John J.; Departments of Medicine1 and Cellular and Molecular Physiology2, Yale University School of Medicine, New Haven, Connecticut 06510 |
