| Автор | Wekerle, Thomas |
| Автор | Sykes, Megan |
| Дата выпуска | 2001 |
| dc.description | ▪ Abstract Achieving transplanatation tolerance is an important goal in the effort to reduce long-term morbidity and mortality in organ transplant recipients. Robust, lifelong, donor-specific tolerance can be reliably achieved by induction of mixed chimerism in various animal models. To date, the clinical application of these proto-cols has been impeded partly by the potential toxicity of the required host conditioning regimens and the lack of successful studies in large animals. This article reviews the progress achieved in recent years in developing considerably milder conditioning protocols in rodents, and in extending some of these models to achieve permanent mixed chimerism and tolerance in large animals. Advances in the induction of xenogeneic tolerance through mixed chimerism are also discussed. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | MIXED CHIMERISM AND TRANSPLANTATION TOLERANCE |
| DOI | 10.1146/annurev.med.52.1.353 |
| Print ISSN | 0066-4219 |
| Журнал | Annual Review of Medicine |
| Том | 52 |
| Первая страница | 353 |
| Последняя страница | 370 |
| Аффилиация | Wekerle, Thomas; Department of Surgery, Vienna General Hospital, University of Vienna, Währingergürtel 18, Vienna, A-1090 Austria; e-mail: Thomas.Wekerle@akh-wien.ac.at |
