| Автор | Mehren, Margaret von |
| Автор | Adams, Gregory P. |
| Автор | Weiner, Louis M. |
| Дата выпуска | 2003 |
| dc.description | Monoclonal antibody therapy has emerged as an important therapeutic modality for cancer. Unconjugated antibodies show significant efficacy in the treatment of breast cancer, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia. Promising new targets for unconjugated antibody therapy include cellular growth factor receptors, receptors or mediators of tumor-driven angiogenesis, and B cell surface antigens other than CD20. Immunoconjugates composed of antibodies conjugated to radionuclides or toxins show efficacy in non-Hodgkin's lymphoma. One immunoconjugate containing an antibody and a chemotherapy agent exhibits clinically meaningful antitumor activity in acute myeloid leukemia. Numerous efforts to exploit the ability of antibodies to focus the activities of toxic payloads at tumor sites are under way and show early promise. The ability to create essentially human antibody structures has reduced the likelihood of host-protective immune responses that otherwise limit the duration of therapy. Antibody structures now can be readily manipulated to facilitate selective interaction with host immune effectors. Other structural manipulations that improve the selective targeting properties and rapid systemic clearance of immunoconjugates should lead to the design of effective new treatments, particularly for solid tumors. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | Monoclonal Antibody Therapy for Cancer |
| DOI | 10.1146/annurev.med.54.101601.152442 |
| Print ISSN | 0066-4219 |
| Журнал | Annual Review of Medicine |
| Том | 54 |
| Первая страница | 343 |
| Последняя страница | 369 |
| Аффилиация | Mehren, Margaret von; Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111; e-mail: m_vonmehren@fccc.edu gp_adams@fccc.edu lm_weiner@fccc.edu |
