| Автор | Lowry, Stephen F. |
| Автор | Foster, David M. |
| Автор | Norton, Jeffrey A. |
| Автор | Berman, Mones |
| Автор | Brennan, Murray F. |
| Дата выпуска | 1981 |
| dc.description | For the study of glucose carbon recycling and incorporation of carbon atoms from plasma alanine into plasma glucose, [3-<sup>3</sup>H)glucose and [U- <sup>14</sup>C)alanine were injected info inbred non-tumor-bearing (NTB) and tumor-bearing (TB) male F344 rats. The glucose and alanine kinetics were determined in relation to antecedent food intake and carcass weight loss. Whereas fed NTB and TB rats appropriately experienced reduced glucose disposal with decreased food intake (0.99 vs. 0.29 mg/min -100<sup>-1</sup> compared with observations in starved NTB rats), starved TB rats exhibited increased glucose utilization. Both fully fed and cachectic TB groups exhibited increased isotopic carbon recycling compared to the carbon recycling of NTB control groups, whereas starved TB rats did not demonstrate increased recycling (27% of C-atoms recycled). These findings suggest that alterations of glucose turnover, carbon recycling, and gluconeogenesis in the fed host parallel hypophagia and weight loss, regardless of TB status. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Investigations on Nonhuman Systems |
| Название | Glucose Disposal and Gluconeogenesis From Alanine in Tumor-Bearing Fischer Gluconeogenesis 344 Rats2 |
| Тип | research-article |
| DOI | 10.1093/jnci/66.4.653 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 66 |
| Первая страница | 653 |
| Последняя страница | 658 |
| Аффилиация | Lowry Stephen F.; Surgical Metabolism Section, Surgery Branch, Division of Cancer Treatment, National Cancer Institute (NCI), National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services |
| Аффилиация | Foster David M.; Mathematical Biology Section, Laboratory of Theoretical Biology, Division of Cancer Biology and Diagnosis |
| Аффилиация | Norton Jeffrey A.; Surgical Metabolism Section, Surgery Branch, Division of Cancer Treatment, National Cancer Institute (NCI), National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services |
| Аффилиация | Berman Mones; Mathematical Biology Section, Laboratory of Theoretical Biology, Division of Cancer Biology and Diagnosis |
| Аффилиация | Brennan Murray F.; Surgical Metabolism Section, Surgery Branch, Division of Cancer Treatment, National Cancer Institute (NCI), National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services |
| Выпуск | 4 |
