| Автор | Mizushima, Yutaka |
| Автор | Sendo, Fujiro |
| Автор | Miyake, Takayoshi |
| Автор | Kobayashi, Hiroshi |
| Дата выпуска | 1981 |
| dc.description | Lethal growth of a syngeneic transplanted tumor (KMT-17) was inhibited in inbred WKA rats pretreated with the anti leukemia drug busulfan (BU). However, the lethal growth of KMT-17 was not inhibited by pretreatment with cyclophosphamide, adriamycin, or ftorafur. With the Winn assay, spleen cells from BU-pretreated KMT-17-bearing rats (TBR) inhibited the growth of admixed KMT-17 cells more strongly than did spleen cells from BU-untreated TBA. The augmented tumor inhibitory activity of spleen cells was KMT-17-specific, and this activity was abrogated by in vitro treatment of spleen cells with anti-T serum and guinea pig complement. Augmentation of the immune response to KMT-17-associated antigen(s) in BU-pretreated TBR was also demonstrated in lymphocyte-mediated cytotoxicity, as detected by a <sup>51</sup>Cr release assay and by a delayed-type hypersensitivity with a radioisotope footpad assay. Tumor regression in BU-pretreated rats was demonstrated to be mediated by the augmentation of T-cell-mediated immune responses to tumorassociated antigens. The tumor inhibitory effect of BU was abrogated by adoptive transfer with thymus cells from normal rats but not with those from BU-pretreated rats 1 day before tumor inoculation. The augmentation of the antitumor immune responses by pretreatment with BU was suggested to be due to the fact that BU selectively inhibited the suppressor cells or their precursors. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Тема | Investigations on Nonhuman Systems |
| Название | Augmentation of Specific Cell-Mediated Immune Responses to Responses to in Tumor-Bearing Rats Pretreated With the Antileukemia Drug Busulfan23 |
| Тип | research-article |
| DOI | 10.1093/jnci/66.4.659 |
| Electronic ISSN | 1460-2105 |
| Print ISSN | 0027-8874 |
| Журнал | JNCI: Journal of the National Cancer Institute |
| Том | 66 |
| Первая страница | 659 |
| Последняя страница | 665 |
| Аффилиация | Mizushima Yutaka; Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine |
| Аффилиация | Sendo Fujiro; Department of Pathology, Yamagata University School of Medicine |
| Аффилиация | Miyake Takayoshi; Department of Pathology, Yamagata University School of Medicine |
| Аффилиация | Kobayashi Hiroshi; Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine |
| Выпуск | 4 |
