Effect of ovarian hormones on the induction of 1-methyl-1-nitrosourea-induced mammary cancer
Grubbs, Clinton J.; Peckham, John C.; McDonough, Karen D.; Grubbs Clinton J.; Kettering-Meyer Laboratory, Southern Research Institute; Peckham John C.; Allied Corporation; McDonough Karen D.; Kettering-Meyer Laboratory, Southern Research Institute
Журнал:
Carcinogenesis
Дата:
1983
Аннотация:
The concomitant administration of 20 μg 17β-estradiol and 4 mg progesterone/injection (5 days/week) over a 40-day treatment period beginning 10 days after methylnitrosourea (MNU) treatment was as effective as ovariectomy in inhibiting mammary cancers (an 84% reduction from non-hormone treated rats). The primary action of the hormones must have been directed at preneoplastic cells since the hormones were not given until 10 days after MNU (a direct-acting carcinogen with a short half-life).
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