| Автор | Gourse, Richard L. |
| Автор | Gaal, Tamas |
| Автор | Bartlett, Michael S. |
| Автор | Appleman, J. Alex |
| Автор | Ross, Wilma |
| Дата выпуска | 1996 |
| dc.description | ▪ Abstract The synthesis of ribosomal RNA is the rate-limiting step in ribosome synthesis in bacteria. There are multiple mechanisms that determine the rate of rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional strength and for regulation in response to nutritional conditions and amino acid availibility. Strength derives in part from an extended RNA polymerase (RNAP) recognition region involving at least two RNAP subunits, in part from activation by a transcription factor and in part from modification of the transcript by a system that prevents premature termination. Regulation derives from at least two mechanistically distinct systems, growth rate–dependent control and stringent control. The mechanisms contributing to rRNA transcription work together and compensate for one another when individual systems are rendered inoperative. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | rRNA TRANSCRIPTION AND GROWTH RATE–DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI |
| DOI | 10.1146/annurev.micro.50.1.645 |
| Print ISSN | 0066-4227 |
| Журнал | Annual Review of Microbiology |
| Том | 50 |
| Первая страница | 645 |
| Последняя страница | 677 |
| Аффилиация | Gourse, Richard L.; Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706; e-mail: rgourse@bact.wisc.edu |
