| Автор | Ishihama, Akira |
| Дата выпуска | 2000 |
| dc.description | ▪ Abstract The promoter recognition specificity of Escherichia coli RNA polymerase is modulated by replacement of the σ subunit in the first step and by interaction with transcription factors in the second step. The overall differentiated state of ∼2000 molecules of the RNA polymerase in a single cell can be estimated after measurement of both the intracellular concentrations and the RNA polymerase-binding affinities for all seven species of the σ subunit and 100–150 transcription factors. The anticipated impact from this line of systematic approach is that the prediction of the expression hierarchy of ∼4000 genes on the E. coli genome can be estimated. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | FUNCTIONAL MODULATION OF ESCHERICHIA COLI RNA POLYMERASE |
| DOI | 10.1146/annurev.micro.54.1.499 |
| Print ISSN | 0066-4227 |
| Журнал | Annual Review of Microbiology |
| Том | 54 |
| Первая страница | 499 |
| Последняя страница | 518 |
| Аффилиация | Ishihama, Akira; National Institute of Genetics, Department of Molecular Genetics, Mishima, Shizuoka 411-8540, Japan; e-mail: aishiham@lab.nig.ac.jp |
