| Автор | Wehling, Klaus |
| Автор | Arfmann, Hans-Adolf |
| Автор | Seipke, Gerhard |
| Автор | Wagner, Karl G. |
| Дата выпуска | 1977 |
| dc.description | Binding affinities towards DNA and base pair specificities of lysine copolymers, containing different amounts of Phe, Tyr or Trp residues, were estimated using a previously described chromatographic method. Incorporation of few aromatic residues into polylysine causes a decrease in the binding affinity, however, further raising the aromatic residue -lysine ratio results in a continous increase of affinity, which is most pronounced with the Tyr copolymers and not observed with polymers containing neutral aliphatic amino acid residues. AT-specificity increases concomitant with binding affinity in the case of the Tyr copolymers but not with the Phe copolymers. The interaction of DNA with the alternating Phe-Lys polymer is significantly stronger than with the random copolymer of equal residue composition. The molecular and conformational reasons determining specificity are discussed. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1977 Information Retrieval Limited |
| Тема | Articles |
| Название | Specificity of DNA-basic polypeptide interactions. 11<sup>+</sup>. Influence of aromatic amino acid residues investigated with agarose bound lysine copolypeptides |
| Тип | research-article |
| Electronic ISSN | 1362-4962 |
| Print ISSN | 0305-1048 |
| Журнал | Nucleic Acids Research |
| Том | 4 |
| Первая страница | 513 |
| Последняя страница | 522 |
| Аффилиация | Gesellschaft für Biotechnologische ForschungAbteilung Molekularbiologie, 3300 Braunschweig-Stöckheim, GFR |
| Выпуск | 3 |
