| Автор | Lee, Philip A. |
| Автор | Tullman-Ercek, Danielle |
| Автор | Georgiou, George |
| Дата выпуска | 2006 |
| dc.description | Abstract The twin-arginine translocation (Tat) pathway is responsible for the export of folded proteins across the cytoplasmic membrane of bacteria. Substrates for the Tat pathway include redox enzymes requiring cofactor insertion in the cytoplasm, multimeric proteins that have to assemble into a complex prior to export, certain membrane proteins, and proteins whose folding is incompatible with Sec export. These proteins are involved in a diverse range of cellular activities including anaerobic metabolism, cell envelope biogenesis, metal acquisition and detoxification, and virulence. The Escherichia coli translocase consists of the TatA, TatB, and TatC proteins, but little is known about the precise sequence of events that leads to protein translocation, the energetic requirements, or the mechanism that prevents the export of misfolded proteins. Owing to the unique characteristics of the pathway, it holds promise for biotechnological applications. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | The Bacterial Twin-Arginine Translocation Pathway |
| DOI | 10.1146/annurev.micro.60.080805.142212 |
| Print ISSN | 0066-4227 |
| Журнал | Annual Review of Microbiology |
| Том | 60 |
| Первая страница | 373 |
| Последняя страница | 395 |
| Аффилиация | Lee, Philip A.; Institute for Cellular and Molecular Biology and 2Departments of Chemical Engineering, 3Biomedical Engineering, and 4Molecular Genetics and Microbiology, University of Texas, Austin, Texas 78712-0231; email: philipl@che.utexas.edu , tullman@che.utexas.edu , gg@che.utexas.edu |
