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Автор Nohmi, Takehiko
Дата выпуска 2006
dc.description Abstract In nature, microbes live under a variety of harsh conditions, such as excess DNA damage, starvation, pH shift, or high temperatures. Microbial cells respond to such stressful conditions mostly by switching global patterns of gene expression to relieve the environmental stress. The SOS response, which is induced by DNA damage, is one such global network of gene expression that plays a crucial role in balancing the genomic stability and flexibility that are necessary to adapt to harsh environments. Here, I review the roles of SOS-inducible and noninducible lesion-bypass DNA polymerases in mutagenesis induced by environmental stress, and discuss how these polymerases are coordinated for the replication of damaged chromosomes. Possible contributions of lesion-bypass DNA polymerase in hyperthermophilic archaea, e.g., Sulfolobus solfataricus, to genome maintenance are also discussed.
Формат application.pdf
Издатель Annual Reviews
Копирайт Annual Reviews
Название Environmental Stress and Lesion-Bypass DNA Polymerases
DOI 10.1146/annurev.micro.60.080805.142238
Print ISSN 0066-4227
Журнал Annual Review of Microbiology
Том 60
Первая страница 231
Последняя страница 253
Аффилиация Nohmi, Takehiko; Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan, email: nohmi@nihs.go.jp

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