| Автор | BERTHELSEN, P. |
| Автор | GØTHGEN, I. |
| Автор | HUSUM, B. |
| Автор | JACOBSEN, E. |
| Дата выпуска | 1986 |
| dc.description | The effects of acetazolamide on renal and erythrocyte carbonic anhydrase were studied in 12 critically ill patients. In the first part of the investigation (n = 6) we examined the renal effects of increasing doses of acetazolamide. The maximal renal excretion of water and bicarbonate was achieved with acetazolamide 2.5–5 mg kg<sup>−1</sup>x i.v. In the second part (n = 6), the associated respiratory effects of the effective renal dose of acetazolamide 5 mg kg<sup>−1</sup> were evaluated. We found a statistically significant 4% decrease in pulmonary carbon dioxide excretion in the 10-min sampling period immediately following the administration of acetazolamide, but thereafter carbon dioxide elimination proceeded at a normal rate. The observed carbon dioxide retention is clinically unimportant, and we recommend acetazolamide as an seffective means of eliminating surplus water and bicarbonate in the critically ill. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1986 British Journal of Anaesthesia |
| Тема | CLINICAL INVESTIGATION |
| Название | DISSOCIATION OF RENAL AND RESPIRATORY EFFECTS OF ACETAZOLAMIDE IN THE CRITICALLY ILL |
| Тип | other |
| Electronic ISSN | 1471-6771 |
| Print ISSN | 0007-0912 |
| Журнал | BJA: British Journal of Anaesthesia |
| Том | 58 |
| Первая страница | 512 |
| Последняя страница | 516 |
| Аффилиация | Department of Anaesthesia2034, RigshospitaletUniversity of CopenhagenBlegdamsvej 9, DK-2100 Copenhagen, Denmark |
| Выпуск | 5 |
