| Автор | Agnew, J. E. |
| Автор | Pavia, D. |
| Автор | Clarke, S. W. |
| Дата выпуска | 1988 |
| dc.description | Lung retention of insoluble Tc-99m particles was measured at 24-h and 48-h in subjects of widely varying lung function. In 10 tests out of 58, clearance between 24-h and 48-h accounted for 10 to 26% of the initial lung deposit, presumably reflecting a continuing tracheobronchial clearance.Retention was analysed relative to lung function for three groups of tests: A, mean inhalation flow rate 20–24 1/min (n = 17); B, 25–30 1/min (n = 20); C, 31–38 1/min (n = 21). Within each group, 48-h retention correlated strongly with forced expiratory volume in 1 s(r > 0.84, p < 0.001) and maximal mid-expiratory flow rate (r > 0.81, p < 0.001). Differences of slope and position between the regression lines for the three groups suggested 48-h retention falling (as expected) with increasing inhalation flow rate in subjects with good lung function —but not in subjects with poor lung function. A substantial fraction of 48-h retention in the latter may represent impactional deposition at tracheobronchial sites. |
| Формат | application.pdf |
| Издатель | The British Occupational Hygiene Society |
| Копирайт | © 1988 The British Occupational Hygiene Society |
| Тема | Session W2. Deposition and Clearance of Inhaled particles in Relation to Lung Dosimetry |
| Название | 24-h and 48-h Retention of 5 μm Polystyrene Particles in Relationship to Lung Function and Inhalation Flow Rate |
| Тип | research-article |
| DOI | 10.1093/annhyg/32.inhaled_particles_VI.969 |
| Electronic ISSN | 1475-3162 |
| Print ISSN | 0003-4878 |
| Журнал | Annals of Occupational Hygiene |
| Том | 32 |
| Первая страница | 969 |
| Последняя страница | 974 |
| Аффилиация | Royal Free HospitalLondon, NW3 2QG |
| Выпуск | inhaled_particles_VI |
