| Автор | Bailey, M. R. |
| Автор | Kreyling, W. G. |
| Автор | Andre, S. |
| Автор | Batchelor, A. |
| Автор | Black, A. |
| Автор | Collier, C. G. |
| Автор | Drosselmeyer, E. |
| Автор | Ferron, G. A. |
| Автор | Foster, P. |
| Автор | Haider, B. |
| Автор | Hodgson, A. |
| Автор | Metivier, H. |
| Автор | Moores, S. R. |
| Автор | Morgan, A. |
| Автор | Müller, H. L. |
| Автор | Patrick, G. |
| Автор | Pickering, S. |
| Автор | Ramsden, D. |
| Автор | Stirling, C. |
| Автор | Talbot, R. J. |
| Дата выпуска | 1988 |
| dc.description | Preliminary results are reported of measurements on baboons, dogs, guinea pigs, rats, hamsters and mice which inhaled 0.8 or 1.7 μm geometric diameter monodisperse <sup>57</sup>Co-labelled cobalt oxide particles. Lung retention at three months ranged from < 30% in rats to > 50% in baboons. Most of the cobalt which cleared from the lung was rapidly excreted. At 6–13 weeks after inhalation of 1.7 μm particles, the fraction of the remaining activity excreted per day in urine ranged from 0.0014 in baboons to 0.008 in dogs, and was approximately twice as high for 0.8 μm particles. Faecal excretion rates were similar for the two sizes, and average rates 6–13 weeks after inhalation ranged from < 0.001 per day in dogs, to > 0.01 per day in the small rodents. Measurements will continue to at least six months after exposure and the study extended to include man. The results, with those of metabolic studies on intravenously injected cobalt, and on ingested cobalt oxide, will be used to derive cobalt translocation rates from the particles in the lung to the blood, and the particle clearance rates to the GI tract for each species. |
| Формат | application.pdf |
| Издатель | The British Occupational Hygiene Society |
| Копирайт | © 1988 The British Occupational Hygiene Society |
| Тема | Session W2. Deposition and Clearance of Inhaled particles in Relation to Lung Dosimetry |
| Название | An Interspecies Comparison of the Translocation of Material from Lung to Blood |
| Тип | research-article |
| DOI | 10.1093/annhyg/32.inhaled_particles_VI.975 |
| Electronic ISSN | 1475-3162 |
| Print ISSN | 0003-4878 |
| Журнал | Annals of Occupational Hygiene |
| Том | 32 |
| Первая страница | 975 |
| Последняя страница | 985 |
| Аффилиация | Bailey M. R.; National Radiological Protection Board |
| Аффилиация | Kreyling W. G.; Gesellschaft für Strahlen- und Umweltforschung mbH München |
| Аффилиация | Andre S.; Commissariat à l'Energie Atomique/ IPSN/SPE/STCE |
| Аффилиация | Batchelor A.; Medical Research Council Radiobiology Unit |
| Аффилиация | Black A.; Atomic Energy Research Establishment |
| Аффилиация | Collier C. G.; National Radiological Protection Board |
| Аффилиация | Drosselmeyer E.; Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie |
| Аффилиация | Ferron G. A.; Gesellschaft für Strahlen- und Umweltforschung mbH München |
| Аффилиация | Foster P.; Atomic Energy Establishment |
| Аффилиация | Haider B.; Gesellschaft für Strahlen- und Umweltforschung mbH München |
| Аффилиация | Hodgson A.; National Radiological Protection Board |
| Аффилиация | Metivier H.; Commissariat à l'Energie Atomique/ IPSN/SPE/STCE |
| Аффилиация | Moores S. R.; Atomic Energy Research Establishment |
| Аффилиация | Morgan A.; Atomic Energy Research Establishment |
| Аффилиация | Müller H. L.; Atomic Energy Research Establishment |
| Аффилиация | Patrick G.; Medical Research Council Radiobiology Unit |
| Аффилиация | Pickering S.; Commission of the European Communities, Joint Research Centre, European Institute for Transuranium Elements |
| Аффилиация | Ramsden D.; Atomic Energy Establishment |
| Аффилиация | Stirling C.; Medical Research Council Radiobiology Unit |
| Аффилиация | Talbot R. J.; Atomic Energy Research Establishment |
| Выпуск | inhaled_particles_VI |
