| Автор | BRUNNER, M. D. |
| Автор | BRAITHWAITE, P. |
| Автор | JHAVERI, R. |
| Автор | MCEWAN, A. I. |
| Автор | GOODMAN, D. K. |
| Автор | SMITH, L. R. |
| Автор | GLASS, P. S. A. |
| Дата выпуска | 1994 |
| dc.description | We have shown previously that a plasma fentanyl concentration of 1.67 ng ml<sup>−1</sup> reduced the MAC of isoflurane by 50%. By comparing equal degrees of MAC reduction by sufentanil, we may determine the potency ratio of these opioids. Seventy-six patients were allocated randomly to receive predetermined infusions of sufentanil, and end-tidal concentrations of isoflurane in oxygen. Blood samples were obtained 10 min after the start of the infusion, and just before and after skin incision. Any purposeful movement by the patient was recorded. The MAC reduction of isoflurane produced by sufentanil was obtained using a logistic regression model. A sufentanil plasma concentration of 0.145 ng ml<sup>−1</sup> (95% confidence limits 0.04, 0.26 ng ml<sup>−1</sup>) resulted in a 50% reduction in the MAC of isoflurane. At a plasma concentration greater than 0.5 ng ml<sup>−1</sup>, sufentanil exhibited a ceiling effect. (Br. J. Anaesth. 1994; 72: 42–46) |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1994 British Journal of Anaesthesia |
| Тема | Anaesthetics, volatile: isoflurane, minimum alveolar concentration |
| Тема | Analgesics, opioid: sufentanil |
| Тема | Potency, minimum alveolar concentration |
| Тема | CLINICAL INVESTIGATIONS |
| Название | MAC reduction of isoflurane by sufentanil |
| Тип | other |
| Electronic ISSN | 1471-6771 |
| Print ISSN | 0007-0912 |
| Журнал | BJA: British Journal of Anaesthesia |
| Том | 72 |
| Первая страница | 42 |
| Последняя страница | 46 |
| Аффилиация | BRUNNER M. D.; Department of Anesthesia, Duke University Medical Center |
| Аффилиация | BRAITHWAITE P.; Department of Anaesthesia, The Royal Hallamshire Hospital |
| Аффилиация | JHAVERI R.; Department of Anesthesia, Duke University Medical Center |
| Аффилиация | MCEWAN A. I.; Department of Anaesthesia, St George's Hospital |
| Аффилиация | GOODMAN D. K.; Department of Anesthesia, Duke University Medical Center |
| Аффилиация | SMITH L. R.; Department of Anesthesia, Duke University Medical Center |
| Аффилиация | GLASS P. S. A.; Department of Anesthesia, Duke University Medical Center |
| Выпуск | 1 |
