| Автор | Musunuru, Kiran |
| Автор | Darnell, Robert B. |
| Дата выпуска | 2001 |
| dc.description | ▪ Abstract Studies of the disorders known as paraneoplastic neurologic degenerations exemplify the successful application of modern molecular biological techniques to diseases, yielding, even for these extremely rare disorders, wide-ranging insight into basic neurobiology, tumor immunity, and autoimmune neurologic disease. Immune responses to paraneoplastic neurologic degeneration antigens, also called onconeural antigens, have been exploited to clone and characterize a number of neuron-specific proteins, including several RNA-binding proteins and new kinds of signaling molecules. The biology and functions of these proteins are reviewed, and a model in which their functions are related to the pathogenesis of autoimmune neurologic disease is discussed. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | PARANEOPLASTIC NEUROLOGIC DISEASE ANTIGENS: RNA-Binding Proteins and Signaling Proteins in Neuronal Degeneration |
| DOI | 10.1146/annurev.neuro.24.1.239 |
| Print ISSN | 0147-006x |
| Журнал | Annual Review of Neuroscience |
| Том | 24 |
| Первая страница | 239 |
| Последняя страница | 262 |
| Аффилиация | Musunuru, Kiran; Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10021; e-mail: darnelr@rockvax.rockefeller.edu musunuk@rockvax.rockefeller.edu |
