4-AMINOPYRIDINE REVERSAL OF FENTANYL-INDUCED RESPIRATORY DEPRESSION IN NORMOCAPNIC AND HYPERCAPNIC PATIENTS
SIA R. L.; ZANDSTRA D. F.
Журнал:
BJA: British Journal of Anaesthesia
Дата:
1981
Аннотация:
Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2, suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine was observed before surgery in patients breathing 67% nitrous oxide in oxygen. 4-Aminopyridine had no effect on breathing when given alone in the absence of fentanyl to patients breathing 67% nitrous oxide in oxygen before surgery.
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