| Автор | MOORE, C. M. |
| Автор | DESBOROUGH, J. P. |
| Автор | POWELL, H. |
| Автор | BURRIN, J. M. |
| Автор | HALL, G. M. |
| Дата выпуска | 1994 |
| dc.description | Serum concentrations of the cytokine, interleukin-6 (IL-6), increase after surgical trauma. IL-6 mediates the synthesis of acute phase proteins and stimulates secretion of pituitary hormones. We have examined the time course of circulating I L-6, and cortisol and growth hormone responses in patients undergoing hysterectomy to determine if IL-6 contributes to the early pituitary hormone changes found during surgery. One group (n = 8) received a standardized general anaesthetic while the remaining patients (n = 8) received extradural analgesia to T4-S5 in addition to a similar general anaesthetic. In the general anaesthesia group, there was a significant increase in serum cortisol and growth hormone concentrations before any changes in I L-6 were detected. Furthermore, in the extradural group, in whom these hormonal responses were attenuated, circulating IL-6 concentrations did not differ significantly from the general anaesthesia group. There were no significant differences between the groups in the acute phase response, as measured by circulating concentrations of C-reactive protein and zinc, but the expected effects of extradural block on circulating metabolites and white cell count were demonstrated. We conclude that IL-6 is unlikely to contribute to the initial increases in secretion of pituitary hormones found during surgery, but a later effect of the cytokine on endocrine responses cannot be excluded. (Br. J. Anaesth. 1994; 72: 272–279) |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Copyright: 1994 British Journal of Anaesthesia |
| Тема | Hormones growth |
| Тема | Hormones glucocorticoid |
| Тема | Metabolism, protein acute phase |
| Тема | Complications: trauma |
| Тема | CLINICAL INVESTIGATIONS |
| Название | Effects of extradural anaesthesia on interleukin-6 and acute phase response to surgery |
| Тип | research-article |
| Electronic ISSN | 1471-6771 |
| Print ISSN | 0007-0912 |
| Журнал | BJA: British Journal of Anaesthesia |
| Том | 72 |
| Первая страница | 272 |
| Последняя страница | 279 |
| Аффилиация | Departments of Anaesthetics and Medicine, Royal Postgraduate Medical School, Hammersmith HospitalLondon W12 ONN |
| Выпуск | 3 |
