| Автор | CHRISTENSEN, J. H. |
| Автор | ANDREASEN, F. |
| Автор | JANSEN, J. A. |
| Дата выпуска | 1981 |
| dc.description | Thiopentone was given to eight women and eight men (60–79 yr). The disappearance of thiopentone from the venous blood was described by a three-compartment open model. The only significant difference between the sexes was a higher initial venous concentration in males. The dose (mg kg <sup>−1</sup>) for induction was 70% of the value (P<0.05) previously reported for a comparable group of younger men and women (20–40 yr). The volumes of distribution V<sub>2</sub> and V<sub>3</sub> were larger in the elderly (P<0.05). The terminal half-lives were increased with advancing age (from 75% to 100% on average) (P≤0.01). The clearance value was 50% greater in the older women than in a group of young women. For all groups a significant correlation between initial drug concentration and k<sub>12</sub> supported the hypothesis that the redistribution rate constant k<sub>12</sub> is the predominant factor in the pharmacokinetic profile of a dose of thiopentone sufficient to obtund the eyelash reflex. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Macmillan Publishers Ltd |
| Тема | CLINICAL INVESTIGATION |
| Название | INFLUENCE OF AGE AND SEX ON THE PHARMACOKINETICS OF THIOPENTONE |
| Тип | research-article |
| Electronic ISSN | 1471-6771 |
| Print ISSN | 0007-0912 |
| Журнал | BJA: British Journal of Anaesthesia |
| Том | 53 |
| Первая страница | 1189 |
| Последняя страница | 1195 |
| Аффилиация | CHRISTENSEN J. H.; Department of Anaesthesiology, Aarhus Kommunehospital |
| Аффилиация | ANDREASEN F.; Division of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus |
| Аффилиация | JANSEN J. A.; Institute of Pharmacology, University of Copenhagen |
| Выпуск | 11 |
