| Автор | FAIRLEY, J. W. |
| Автор | REYNOLDS, F. |
| Дата выпуска | 1981 |
| dc.description | The duration of action and vascular effects of L(+) and D(−) and racemic mepivacaine were investigsted in a double-blind study in 23 fit volunteers. Isosmolar 0.1-ml intradermal injections of a range of concentrations of each agent from 0.011% to 2.7%, and physiological saline were given in duplicate to at least 14 subjects. Local colour changes were observed 5–10 min after injection, and analgesia to pinprick was tested at 5-min intervals thereafter until full recovery. Both isomers were vasoconstrictor at concentrations of 0.3% and less; at greater concentration the L isomer produced more vasodilatation and haemorrhagic change. The duration of action of both isomers increased with concentration between 0.05 and 0.9%, but the L isomer was significantly longer acting than the D at 0.3% and more. The log dose-duration curve could be interpreted as linear between 0.1 and 0.9% with the slope of L isomer being twice as steep as the D. The findings for racemic mepivacaine were between those of the two isomers. The longer duration of analgesia of L-mepivacaine was not associated with superior vasoconstrictor power. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © Macmillan Publishers Ltd |
| Тема | EXPERIMENTAL |
| Название | AN INTRADERMAL STUDY OF THE LOCAL ANAESTHETIC AND VASCULAR EFFECTS OF THE ISOMERS OF MEPIVACAINE |
| Тип | research-article |
| Electronic ISSN | 1471-6771 |
| Print ISSN | 0007-0912 |
| Журнал | BJA: British Journal of Anaesthesia |
| Том | 53 |
| Первая страница | 1211 |
| Последняя страница | 1216 |
| Аффилиация | Anaesthetic Unit, St Thomas's Hospital Medical SchoolLondon SE1 7EH |
| Аффилиация | FAIRLEY J. W.; St Helier Hospital |
| Выпуск | 11 |
