| Автор | HENNEBERG, ALEXANDRA E. |
| Автор | BÖGER, PETER |
| Автор | SAHNWALDT, FRITHJOF |
| Автор | DUMKE, HANS O. |
| Автор | KORNHUBER, HANS H. |
| Дата выпуска | 1993 |
| dc.description | Sera of 30 chronic alcoholic patients and 30 age-matched and gender-matched controls were examined for antibodies to brain tissues. We performed an indirect immunofluorescence assay using the patients' and controls' sera as first antibodies, and fluoresceinconjugated anti-human-immunoglobulin Ig-A, Ig-G and Ig-M as second antibodies, on frozen sections of normal human brain. Binding to neuronal cell nuclei of frontal cortex and septal area was found in 40% of patients, but only in 6.7% of controls. The antibodies belonged to the IgM, and additionally sometimes the IgA and IgG subclass. The relevance of these antibodies for the development of brain disease in chronic alcoholic patients is discussed. |
| Формат | application.pdf |
| Издатель | Oxford University Press |
| Копирайт | © 1993 Medical Council on Alcoholism |
| Тема | Articles |
| Название | ANTIBRAIN ANTIBODIES IN ALCOHOLIC PATIENTS |
| Тип | research-article |
| Electronic ISSN | 1464-3502 |
| Print ISSN | 0735-0414 |
| Журнал | Alcohol and Alcoholism |
| Том | 28 |
| Первая страница | 181 |
| Последняя страница | 187 |
| Аффилиация | HENNEBERG ALEXANDRA E.; Department of Neurology, University of Ulm |
| Аффилиация | BÖGER PETER; Department of Neurology, University of Ulm |
| Аффилиация | SAHNWALDT FRITHJOF; Psychiatric Hospital |
| Аффилиация | DUMKE HANS O.; Department of Neurology, University of Ulm |
| Аффилиация | KORNHUBER HANS H.; Department of Neurology, University of Ulm |
| Выпуск | 2 |
