Unusual RNA and DNA binding properties of a novel pyrrolidineâ amide oligonucleotide mimic (POM)Electronic supplementary information (ESI) available: UV thermal denaturation curves, Job plots and SPR sensograms for TS-POM 3 binding to DNA and RNA. See http://www.rsc.org/suppdata/cc/b0/b006903p/
Hickman, David T.; King, Paul M.; Cooper, Matthew A.; Slater, Jonathan M.; Micklefield, Jason; Hickman David T.; Department of Chemistry, UMIST, Faraday Building; King Paul M.; Department of Chemistry, Birkbeck College, University of London; Cooper Matthew A.; University Chemical Laboratory; Slater Jonathan M.; Department of Chemistry, Birkbeck College, University of London; Micklefield Jason; Department of Chemistry, UMIST, Faraday Building
Журнал:
Chemical Communications
Дата:
2000
Аннотация:
A pentameric thymidyl pyrrolidineâ amide oligonucleotide mimic (POM) was synthesised and shown to bind with very high affinity to complementary single stranded RNA and DNA, whilst exhibiting kinetic binding selectivity for RNA over DNA.
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