Издательство Taylor&Francis по журналам "Journal of Biopharmaceutical Statistics"
Отображаемые элементы 120 из 159

(Marcel Dekker, Inc., 19940101)Unknown amounts of drug from plasma samples are determined from inverse prediction of a calibration line. A statistician's criteria for accuracy and three methods for computing precision are given.

(Marcel Dekker, Inc., 19910101)Onesided tests provide actual type I error probabilities that are consistent with specified alpha levels in situations where differences in only one direction will ever be the basis for a consequential claim of significance. ...

(Marcel Dekker, Inc., 19940101)An analytic solution proposed by Senn (1) for removing the effects of covariate imbalance in controlled clinical trials was subjected to Monte Carlo evaluation. For practical applications of his derivation, Senn proposed ...

(Marcel Dekker, Inc., 19920101)Two methods of estimating expiration date have been compared. For a drug whose potency is expected to decrease with time, method 1 fits a linear regression line to the stability data, calculates a 95% lower confidence limit ...

(Marcel Dekker, Inc., 19920101)While a large portion of pharmaceutical stability data is known to follow an exponential model decay, linear modeling of this data for expiry estimation is the norm. Expiry predictions based on linear and exponential fits ...

(Marcel Dekker, Inc., 19940101)Four multidose animal carcinogenicity assay trend test procedures based on the chisquare, HoelWalburg, logrank, and Peto procedures are compared under conditions of competing risks. A total of 42 different risk populations ...

(Marcel Dekker, Inc., 19910101)The distance between two variances is usually measured using the ratio, and a confidence interval for this ratio can be used to measure its magnitude. For a twobytwo crossover study, special considerations must be made ...

(Marcel Dekker, Inc., 19930101)A lognormal model is developed for testing π1, the probability that a subject's response will fall within given bioequivalence limits. The model is a parametric analog of Anderson and Hauck's TIER rule. Confidence intervals ...

(Marcel Dekker, Inc., 19920101)The purpose of this paper is to describe, illustrate, and compare a number of different approaches to the analysis of repeated binary and categorical data. These approaches include empirical generalized least squares and ...

(Marcel Dekker, Inc., 19910101)A dualexposure drug treatment of cell lines in tissue culture provides a possible method for determining schedule dependency. This is suggested by results of treatment of human small cell lung carcinoma NIH H209 and murine ...

(Marcel Dekker, Inc., 19940101)A modelbased approach is developed to estimate the distribution of time from seroconversion to diagnosis with acquired immunodeficiency syndrome (AIDS) as a function of selected timedependent covariates. The approach is ...

(Marcel Dekker, Inc., 19960101)Blood pressure is not constant over the course of a 24h period, but exhibits a predictable and characteristic rise and decline during the day. Although the general shape of this pattern is similar from patient to patient ...

(Marcel Dekker, Inc., 19960101)Clinical studies investigate the interdependence of dosing regimen, efficacy, and side effects. These relationships often involve complex dynamical functions. The study of phenomena intermediate between dosing and efficacy, ...

(Marcel Dekker, Inc., 19940101)In multipledose bioequivalence studies, it is possible at steady state to take repeated measurements of pharmacokinetic variables, such as area under the curve (AUC) and the maximum concentration (CMAX) of the blood ...

(Marcel Dekker, Inc., 19930101)The use of a composite response to estimate the relative potency in a multivariate parallel–line bioassay is described by Finney (1). Occasionally a multivariate bioassay has multiple drugs also. Such a situation arises, ...

(Marcel Dekker, Inc., 19960101)In clinical trials and behavioral sciences, there exist situations where paired responses are obtained from each subject on an ordinal scale. Existing methods for analyzing such data in a factorial design are reviewed and ...

(Marcel Dekker, Inc., 19960101)A method of stratifying the data according to the patterns of missing observations, summarizing each subject's repeated measurements by a summary measure and then comparing the treatment groups with the help of a ...

(Marcel Dekker, Inc., 19930101)Subsampling can be used in experimental design to investigate extraneous sources of variability. One useful strategy is to make independent replicate measurements of the response variate. This can be achieved in clinical ...

(Marcel Dekker, Inc., 19960101)Studies using crossover designs typically involve observations on a large number of response variables made on each of a relatively small number of subjects. Moreover, investigators often observe the responses longitudinally ...

(Marcel Dekker, Inc., 19960101)Several complex clinical and statistical issues are involved in the development of a combination drug product. The medical rationale for the combination, the intended clinical use, drugdrug interactions, and dose response ...
Отображаемые элементы 120 из 159