1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor
Wiles, Charlotte; Watts, Paul; Haswell, Stephen J.; Pombo-Villar, Esteban; Wiles Charlotte; Department of Chemistry, Faculty of Science and the Environment, University of Hull; Watts Paul; Department of Chemistry, Faculty of Science and the Environment, University of Hull; Haswell Stephen J.; Department of Chemistry, Faculty of Science and the Environment, University of Hull; Pombo-Villar Esteban; Nervous Systems Research, WSJ-386.07.15, Novartis Pharma Ltd
Журнал:
Lab on a Chip
Дата:
2002
Аннотация:
We demonstrate the formation of a series of diketone enolates and their subsequent reaction with α,β-unsaturated carbonyl compounds in order to prepare a variety of Michael adducts. In all cases, the conversions observed within a micro reactor were greater than those obtained in batch.
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