| dc.description |
(±)-α-Cyclogeraniol and (±)-drim-7-en-11-ol acetates obtainedviathe FSO3H-induced cyclisation of geraniol and (E)-farnesol and subsequent acetylation were hydrolysed in the presence of hog pancreas lipase (PPL) to afford (R)-(+)-α-cyclogeraniol (ee~30% at the optimal conversionC= 20±2%) and (5R,9R,10R)-(+)-drim-7-en-11-ol (ee78.5% atC= 30%), respectively; (±)-15-acetoxyisoagath-12-ene, obtained similarly from all-E-geranylgeraniol, is resistant to PPL-mediated hydrolysis, but is hydrolysed in the presence of lipase fromCandida cylindraceato afford (10S,14R)-(â )-isoagath-12-en-15-ol of 69-80%eein ~3% yield. |
