| Автор | DinsmorePresent address: Department of Chemistry, University of Witwatersrand, PO WITS 2050, South Africa., Andrew |
| Автор | DoylePresent address: BioFocus plc, 130 Abbott Drive, Sittingbourne Research Centre, Sittingbourne, Kent, UK ME9 8AZ., Paul M. |
| Автор | Young, Douglas W. |
| Дата выпуска | 2001 |
| dc.description | (2S)-2-Amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propionic acid 8, an isomer of the natural product willardiine 7, was synthesised by treatment of the pyroglutamate urea 19 with mild base followed by deprotection in a two-step modification of our â ring-switchingâ approach to the synthesis of glutamate antagonists. Use of this two-step strategy has allowed us to synthesise l-alanine derivatives, which are β-substituted by a reduced pyrimidinedione which contains a second chiral centre. In one case, the antagonist activity at metabotropic glutamate receptors of two diastereoisomers showed little difference. |
| Формат | application.pdf |
| Издатель | Royal Society of Chemistry |
| Название | Use of a modified ring-switching strategy to synthesise the glutamate antagonist (2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propionate and related compounds with two chiral centres1 |
| Тип | research-article |
| DOI | 10.1039/b109820a |
| Electronic ISSN | 1364-5463 |
| Print ISSN | 0300-922X |
| Журнал | Journal of the Chemical Society, Perkin Transactions 1 |
| Первая страница | 155 |
| Последняя страница | 164 |
| Аффилиация | DinsmorePresent address: Department of Chemistry, University of Witwatersrand, PO WITS 2050, South Africa. Andrew; Sussex Centre for Biomolecular Design and Drug Development, University of Sussex |
| Аффилиация | DoylePresent address: BioFocus plc, 130 Abbott Drive, Sittingbourne Research Centre, Sittingbourne, Kent, UK ME9 8AZ. Paul M.; Sussex Centre for Biomolecular Design and Drug Development, University of Sussex |
| Аффилиация | Young Douglas W.; Sussex Centre for Biomolecular Design and Drug Development, University of Sussex |
| Выпуск | 2 |
| Библиографическая ссылка | A. Dinsmore, P. M. Doyle, P. B. Hitchcock, D. W. Young, Part of this work has been published in preliminary form in , Tetrahedron Lett., 2000, 41, 10153 |
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