| Автор | Urizar, Nancy L. |
| Автор | Moore, David D. |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | GUGULIPID: A Natural Cholesterol-Lowering Agent |
| DOI | 10.1146/annurev.nutr.23.011702.073102 |
| Print ISSN | 0199-9885 |
| Журнал | Annual Review of Nutrition |
| Том | 23 |
| Первая страница | 303 |
| Последняя страница | 313 |
| Аффилиация | Urizar, Nancy L.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030; email: nurizar@bcm.tmc.edu moore@bcm.tmc.edu |
