| Автор | McEligot, Archana Jaiswal |
| Автор | Yang, Sun |
| Автор | Meyskens, Jr., Frank L. |
| Дата выпуска | 2005 |
| dc.description | ▪ Abstract Cells in multicellular organisms are exposed to both endogenous oxidative stresses generated metabolically and to oxidative stresses that originate from neighboring cells and from other tissues. To protect themselves from oxidative stress, cells are equipped with reducing buffer systems (glutathione/GSH and thioredoxin/thioredoxin reductase) and have developed several enzymatic mechanisms against oxidants that include catalase, superoxide dismutase, and glutathione peroxidase. Other major extrinsic defenses (from the diet) include ascorbic acid, β-carotene and other carotenoids, and selenium. Recent evidence indicates that in addition to their antioxidant function, several of these redox species and systems are involved in regulation of biological processes, including cellular signaling, transcription factor activity, and apoptosis in normal and cancer cells. The survival and overall well-being of the cell is dependent upon the balance between the activity and the intracellular levels of these antioxidants as well as their interaction with various regulatory factors, including Ref-1, nuclear factor-κB, and activating protein-1. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | REDOX REGULATION BY INTRINSIC SPECIES AND EXTRINSIC NUTRIENTS IN NORMAL AND CANCER CELLS |
| DOI | 10.1146/annurev.nutr.25.050304.092633 |
| Print ISSN | 0199-9885 |
| Журнал | Annual Review of Nutrition |
| Том | 25 |
| Первая страница | 261 |
| Последняя страница | 295 |
| Аффилиация | McEligot, Archana Jaiswal; Departments of Medicine (1Epidemiology and 2Hematology/Oncology Divisions) and 3Biological Chemistry, Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California 92868; email: mceligot@uci.edu , syang2@uci.edu , flmeyske@uci.edu |
