Manganese(iii) acetate-mediated alkylation of β-keto esters and β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones
Bar, Gregory; Parsons, Andrew F.; Barry Thomas, C.; Bar Gregory; Department of Chemistry, University of York; Parsons Andrew F.; Department of Chemistry, University of York; Barry Thomas C.; Department of Chemistry, University of York
Журнал:
Organic & Biomolecular Chemistry
Дата:
2002
Аннотация:
β-Keto esters and β-keto amides can be efficiently alkylated on reaction with enol ethers and manganese(iii) acetate in the presence of copper(ii) acetate. These intermolecular radical addition reactions can be used to construct quaternary carbon centres in excellent yield and this method has been utilised in a diastereoselective approach to substituted pyrrolidinones.
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