Chapter 4. Biologically Active N-Heterocyclic Carbene–Metal Complexes
Deblock, Michael C.; Panzner, Matthew J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J.; Deblock Michael C.; Center for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of Akron; Panzner Matthew J.; Center for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of Akron; Tessier Claire A.; Center for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of Akron; Cannon Carolyn L.; School of Medicine, Pediatrics, University of Texas Southwestern Medical Center; Youngs Wiley J.; Center for Silver Therapeutics Research, Department of Chemistry and Integrated Bioscience Program, Buchtel College of Arts and Sciences, University of Akron
Журнал:
N-Heterocyclic Carbenes
Дата:
2011
Аннотация:
The increasing popularity of N-heterocyclic carbenes (NHCs) has yield in the past few years numerous new and exciting applications of these species, particularly as ligands in metal complexes. Complementarily, these ligands could have a prominent role in the development of new metallopharmaceuticals. Thanks to the number of different NHCâ metal compounds that can be synthesized a wide variety of applications have emerged as bio-inorganic pharmaceuticals. Medicinal uses studied so far include powerful broad spectrum antibiotics and targeted antitumor agents.
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