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Автор Panagiotou, T.
Автор Chomistek, K.J.
Автор Fisher, R.J.
Дата выпуска 2012
ISBN 978-1-84973-378-6
dc.description Microfluidics Reaction Technology (MRT is a continuous processing technology used to produce stable nano-scale materials through crystallization, precipitation, emulsification, and chemical reactions. High purity materials with controlled structure and desired properties were produced successfully using this platform technology. The principles upon which this platform is based are the fundamental rates of mass, heat, and momentum transfer coupled with chemical reaction phenomena. The essential physical component is a continuous and scalable micro-reactor utilizing impinging jets. Flow throughput is characterized by high fluid velocities, up to 500 m/s, resulting in highly turbulent conditions and interactions at the nano-scale. In addition to size control, the technology offers control of morphologies and reaction selectivity. The unique design of this micro-reactor provides precise control of feed rates, mixing location and its intensity, and process time scales. Successful implementations of this platform technology include: (a) formation of drug nano-suspensions through crystallization, (b) nano-encapsulation of actives in polymers, and (c) chemical reacting systems that produce and/or utilize nano-species, such as suspensions and emulsions. The focus here is on the production of nano- emulsions and global system optimization. Results indicate that they can be formed in one step using MRT as opposed to the two step conventional process that requires the initial formation of a micro-emulsion. Also demonstrated are the reduced amounts of surfactants required for certain formulations to obtain stable nano-emulsions. Dependent upon process parameters, sizes in the range of 50-800 nm are easily obtained.
Формат application.pdf
Издатель Royal Society of Chemistry
Название Microfluidics Reaction Technology (MRT) for Continuous Production for Nano-formulations of Drug Entities and Advanced Materials
Тип other
DOI 10.1039/9781849735247-00135
Print ISSN 0260-6291
Журнал NanoFormulation
Первая страница 135
Последняя страница 149

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