| Автор | Es-haghi, Ali |
| Автор | Zhang, Xu |
| Автор | Musteata, Florin Marcel |
| Автор | Bagheri, Habib |
| Автор | Pawliszyn, Janusz |
| Дата выпуска | 2007 |
| dc.description | Solid-phase microextraction probes based on poly(ethylene glycol)/C18-bonded silica were used for in vivo monitoring of drugs from circulating blood of beagles, over a period of 8 h. After sampling, the extracted drugs were subsequently quantified by liquid chromatography coupled with tandem mass spectrometry. External calibrations in whole blood and phosphate-buffered saline were used to correlate the amount of analytes extracted in regard to the total and free concentrations in blood respectively. The probe provided sufficient sensitivity for the drugs in the blood matrix, while the need for drawing blood was eliminated. The limit of detections of the method from whole blood were 1.7, 1.4 and 2.8 ng mL<sup>â 1</sup> for the analysis of diazepam, nordiazepam and oxazepam respectively, and the linear range was from 4 ng mL<sup>â 1</sup> to 2 μg mL<sup>â 1</sup>. The method was applied for the monitoring of pharmacokinetic profiles of intravenous administration of diazepam and its two main metabolites in dogs, and the results were compared with profiles determined by conventional methods. This approach offered increased sensitivity and accuracy, short extraction time, and convenient calibration for in vivo sampling for dynamic monitoring. |
| Формат | application.pdf |
| Издатель | Royal Society of Chemistry |
| Название | Evaluation of bio-compatible poly(ethylene glycol)-based solid-phase microextraction fiber for in vivo pharmacokinetic studies of diazepam in dogs |
| Тип | research-article |
| DOI | 10.1039/b701423f |
| Electronic ISSN | 1364-5528 |
| Print ISSN | 0003-2654 |
| Журнал | Analyst |
| Том | 132 |
| Первая страница | 672 |
| Последняя страница | 678 |
| Аффилиация | Es-haghiPermanent address: Department of Chemistry, Sharif University of Technology, Azadi Av., P.O. Box 11365-9516, Tehran, Iran. Ali; Department of Chemistry, University of Waterloo |
| Аффилиация | Zhang Xu; Department of Chemistry, University of Waterloo |
| Аффилиация | Musteata Florin Marcel; Department of Chemistry, University of Waterloo |
| Аффилиация | Bagheri Habib; Department of Chemistry, University of Waterloo |
| Аффилиация | Pawliszyn Janusz; Department of Chemistry, University of Waterloo |
| Выпуск | 7 |
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