Amperometric Drug Response of a DNA Membrane Electrode Based on the Enzyme-mimic Catalytic Activity of a DNA–Copper(II) Complex
Hasebe, Yasushi; Hamada, Koji; Hirano, Takuya; Uchiyama, Shunichi
Журнал:
Analytical Communications
Дата:
1997
Аннотация:
The catalytic activity of a DNAâ Cu<sup>II</sup> complex for the oxidation of aminoethanethiol is reversibly inhibited by intercalation with the DNA-binding drug quinacrine, in a concentration dependent manner,which could be detected via an amperometric signal by using a DNAâ Cu<sup>II</sup> complex entrapping hydrogel and an oxygen electrode.
29.26Кб