| Автор | Birch, Anthony J. |
| Автор | Jackson, Anthony H. |
| Автор | Shannon, Patrick V. R. |
| Дата выпуска | 1974 |
| dc.description | Schiffʼs bases formed from a variety of alkoxybenzaldehydes and aminoacetaldehyde dimethyl acetal have been hydrogenated to the corresponding benzylamines and converted into N-tosylates. The latter are readily cyclised in dilute mineral acid to isoquinolines in a one-pot reaction; intermediates in this reaction are N-tosyl-1,2-dihydroisoquinolines which can be isolated. N-Benzyl-N-tosylaminoacetaldehyde dimethyl acetal on treatment with dilute acid under the same conditions as for the cyclisation reactions gave N-benzyl-N-tosylaminoacetaldehyde, and then N-tosylbenzylamine; other substituted benzylamino-acetal derivatives similarly when the benzyl group lacked sufficiently activating substituents for cyclisation of the acetal. |
| Формат | application.pdf |
| Издатель | Royal Society of Chemistry |
| Название | A new modification of the pomeranz–fritsch isoquinoline synthesis |
| Тип | research-article |
| DOI | 10.1039/P19740002185 |
| Electronic ISSN | 1364-5463 |
| Print ISSN | 0300-922X |
| Журнал | Journal of the Chemical Society, Perkin Transactions 1 |
| Первая страница | 2185 |
| Последняя страница | 2190 |
