| Автор | Craig, Peter R. |
| Автор | Brothers, Penelope J. |
| Автор | Clark, George R. |
| Автор | Wilson, William R. |
| Автор | Denny, William A. |
| Автор | Ware, David C. |
| Дата выпуска | 2004 |
| dc.description | Synthetic approaches to cobalt(iii) complexes [Co(L)(Lâ ²)2] containing the bidentate dialkylating nitrogen mustard N,N-bis(2-chloroethyl)-1,2-ethanediamine (L = dce) together with anionic ancilliary ligands (Lâ ²) which are either carbonato (CO3<sup>2â </sup>), oxalato (ox<sup>2â </sup>), bis(2-hydroxyethyl)dithiocarbamato (bhedtc<sup>â </sup>), 2-pyridine carboxylato (pico<sup>â </sup>) or 2-pyrazine carboxylato (pyzc<sup>â </sup>) were investigated. Synthetic routes were developed using the related amines N,N-diethyl-1,2-ethanediamine (dee) and 1,2-ethanediamine (en). The complexes [Co(CO3)2(L)]<sup>â </sup> (L = dee 1, dce 2), [Co(ox)2(L)]<sup>â </sup> (L = dee 3, dce 4), [Co(bhedtc)2(dee)]<sup>+</sup> 5, [Co(bhedtc)2(en)]<sup>+</sup> 6, mer-[Co(pico)3], mer-[Co(pyzc)]3 7 and [Co(pico)2(dee)]<sup>+</sup> 8 were prepared and were characterised by IR, UV-Vis, <sup>1</sup>H and <sup>13</sup>C{<sup>1</sup>H} NMR spectroscopy, mass spectrometry and cyclic voltammetry. [Co(bhedtc)2(en)]BPh4 6b and trans(O)-[Co(pico)2(dee)]ClO4 8 were characterised by X-ray crystallography. In vitro biological tests were carried out on complexes 1â 4 in order to assess the degree to which coordination of the mustard to cobalt attenuated its cytotoxicity, and the differential toxicity in air vs. nitrogen. |
| Формат | application.pdf |
| Издатель | Royal Society of Chemistry |
| Название | Anionic carbonato and oxalato cobalt(iii) nitrogen mustard complexesElectronic supplementary information (ESI) available: Table of hydrogen bonds for 6b and 8. See http://www.rsc.org/suppdata/dt/b3/b311091e/ |
| Тип | research-article |
| DOI | 10.1039/b311091e |
| Electronic ISSN | 1477-9234 |
| Print ISSN | 1477-9226 |
| Журнал | Dalton Transactions |
| Первая страница | 611 |
| Последняя страница | 618 |
| Аффилиация | Craig Peter R.; Department of Chemistry, Faculty of Science, The University of Auckland |
| Аффилиация | Brothers Penelope J.; Department of Chemistry, Faculty of Science, The University of Auckland |
| Аффилиация | Clark George R.; Department of Chemistry, Faculty of Science, The University of Auckland |
| Аффилиация | Wilson William R.; Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences, The University of Auckland |
| Аффилиация | Denny William A.; Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences, The University of Auckland |
| Аффилиация | Ware David C.; Department of Chemistry, Faculty of Science, The University of Auckland; Auckland Cancer Society Research Centre, Faculty of Medicine and Health Sciences, The University of Auckland |
| Выпуск | 4 |
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