The use of <sup>10</sup>B to enhance the tumour dose in fast-neutron therapy
F M Waterman; F T Kuchnir; L S Skaggs; D K Bewley; B C Page; F H Attix; F M Waterman; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA; F T Kuchnir; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA; L S Skaggs; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA; D K Bewley; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA; B C Page; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA; F H Attix; Dept. of Radiology & the Franklin McLean Memorial Res. Inst., Univ. of Chicago, Chicago, IL, USA
Журнал:
Physics in Medicine and Biology
Дата:
1978-07-01
Аннотация:
Incorporation of <sup>10</sup>B in tumours treated by fast-neutron therapy would increase the tumour dose via the reaction <sup>10</sup>B(n, alpha )<sup>7</sup>Li which occurs with partially thermalised neutrons. The extent of the dose enhancement was measured for neutron beams with median energies of 2.4, 3.3, 7.0 and 9.0 MeV by two techniques: with a BF<sub>3</sub> proportional counter in three beams and activation of <sup>23</sup>Na in the fourth. The results obtained with the two techniques are in good agreement. The magnitude of the dose enhancement depends upon the depth, field size and neutron beam energy. The products of the reaction in <sup>10</sup>B would have an RBE about twice that of the fast-neutron dose in the absence of boron.
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