| Автор | S J S Ryde |
| Автор | W D Morgan |
| Автор | C J Evans |
| Автор | A Sivyer |
| Автор | J Dutton |
| Дата выпуска | 1989-10-01 |
| dc.description | A novel clinical instrument for multi-element in vivo neutron activation analysis has been recently constructed in Swansea. The instrument is intended primarily for prompt gamma measurement of total and partial body calcium, total body nitrogen and partial body cadmium. For the measurement of nitrogen the subject is scanned both prone and supine across a vertical collimated neutron beam from a 4 GBq <sup>252</sup>Cf source. Two shielded NaI(Tl) detectors, each of volume 2760 cm<sup>3</sup>, are placed above the subject on the opposite side to that irradiated. The prompt gamma ray spectrum contains prominent peaks from hydrogen, nitrogen, chlorine and carbon. The optimisation, calibration and evaluation of the instrument for the measurement of nitrogen, by the reaction <sup>14</sup>N(n, gamma )<sup>15</sup>N, is described. The calibration corrects the ratio of nitrogen-to-hydrogen counts measured from the subject for background gamma rays and the effects of body habitus. Body hydrogen is used as an internal standard. Repeated measurements of a homogeneous anthropomorphic phantom indicate that the ratio of nitrogen-to-hydrogen counts may be determined with a coefficient of variation of 1.6% for a neutron dose equivalent incident on the phantom of 0.45 mSv (QF=10). The accuracy of the calibration was assessed by measuring three anthropomorphic phantoms (weight range: 41.4-110 kg) containing simulated skeletons and the major organs of the body. For these phantoms the mean discrepancy of the measured to the known nitrogen content was +4.9%. The simultaneous measurement of chlorine and carbon is discussed. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Calibration and evaluation of a <sup>252</sup>CF-based neutron activation analysis instrument for the determination of nitrogen in vivo |
| Тип | paper |
| DOI | 10.1088/0031-9155/34/10/006 |
| Electronic ISSN | 1361-6560 |
| Print ISSN | 0031-9155 |
| Журнал | Physics in Medicine and Biology |
| Том | 34 |
| Первая страница | 1429 |
| Последняя страница | 1441 |
| Аффилиация | S J S Ryde; Dept. of Med. Phys. & Clinical Eng., Singleton Hospital, Swansea, UK |
| Аффилиация | W D Morgan; Dept. of Med. Phys. & Clinical Eng., Singleton Hospital, Swansea, UK |
| Аффилиация | C J Evans; Dept. of Med. Phys. & Clinical Eng., Singleton Hospital, Swansea, UK |
| Аффилиация | A Sivyer; Dept. of Med. Phys. & Clinical Eng., Singleton Hospital, Swansea, UK |
| Аффилиация | J Dutton; Dept. of Med. Phys. & Clinical Eng., Singleton Hospital, Swansea, UK |
| Выпуск | 10 |
