| Автор | Matthias Kohl |
| Автор | Ute Lindauer |
| Автор | Georg Royl |
| Автор | Marc Kühl |
| Автор | Lorenz Gold |
| Автор | Arno Villringer |
| Автор | Ulrich Dirnagl |
| Дата выпуска | 2000-12-01 |
| dc.description | We used Monte Carlo simulations and the diffusion approximation to estimate correction terms for the analysis of reflectance spectra of cortical intrinsic optical signals. These corrections depend on scattering and absorption properties, i.e. they are dependent on assumptions on the tissue blood content and oxygen saturation. The analysis was applied to reflectance spectra acquired during whisker barrel stimulation in the rat where attenuation spectra were converted to changes in oxygenated and deoxygenated haemoglobin concentration. The description of the experimental data as judged by the residual and sensitivity to variations of wavelength was considerably improved when the correction terms were included. Inclusion of the correction does have a considerable impact on the time course of deoxyhaemoglobin concentration changes. In contrast to the calculation without correction terms, there is no indication for an early increase in deoxyhaemoglobin (`early dip'). This finding might further current interpretation of the coupling between neuronal activation and oxygen extraction and supply. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Physical model for the spectroscopic analysis of cortical intrinsic optical signals |
| Тип | paper |
| DOI | 10.1088/0031-9155/45/12/317 |
| Electronic ISSN | 1361-6560 |
| Print ISSN | 0031-9155 |
| Журнал | Physics in Medicine and Biology |
| Том | 45 |
| Первая страница | 3749 |
| Последняя страница | 3764 |
| Аффилиация | Matthias Kohl; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Ute Lindauer; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Georg Royl; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Marc Kühl; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Lorenz Gold; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Arno Villringer; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Аффилиация | Ulrich Dirnagl; Department of Neurology, Charité, Humboldt University Berlin, Schumann Strasse 20/21, 10117 Berlin, Germany |
| Выпуск | 12 |
