The Absorption of Cobalt from the Gastro-intestinal Tract of the Rat
D M Taylor; D M Taylor; Department of Physics, Institute of Cancer Research, Royal Cancer Hospital, London, S.W.3
Журнал:
Physics in Medicine and Biology
Дата:
1962-01-01
Аннотация:
A radioactive tracer technique based on the measurement of the radioactivity appearing in the urine following oral administration of <sup>58</sup>Co has been used to study the effect of a number of substances and cobalt concentrations on the absorption of cobalt from the gastro-intestinal tract of the rat. Following the oral administration of tracer amounts of <sup>58</sup>Co, as cobaltous or cobaltic chloride or as complexes of the cobaltous ion with glycine, blood serum, or lactose, about 30 per cent of the metal is absorbed. Absorption is increased to about 40 per cent when the cobalt is administered in cow's milk. Histidine, lysine, glycylglycine, EDTA, casein and cobaltic glycine complex all depress the absorption of the metal. Administration of larger amounts of cobalt results in the percentage absorption decreasing by a factor of about 2 as the dose rises to 100 μgms; from 100 to 1000 μgms the percentage absorption decreases very slowly indicating that the rat has only a very limited ability to regulate the total amount of cobalt absorbed from the gastro-intestinal tract.
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