Radioactive materials have been used in Ghana for more than four decades. Radioactive waste generated from their applications in various fields has been managed without adequate infrastructure and any legal framework to control and regulate them. The expanded use of nuclear facilities and radiation sources in Ghana with the concomitant exposure to human population necessitates effective infrastructure to deal with the increasing problems of waste. The Ghana Atomic Energy Act 204 (1963) and the Radiation Protection Instrument LI 1559 (1993) made inadequate provision for the management of waste. With the amendment of the Atomic Energy Act, PNDCL 308, a radioactive waste management centre has been established to take care of all waste in the country. To achieve the set objectives for an effective waste management regime, a waste management regulation has been drafted and relevant codes of practice are being developed to guide generators of waste, operators of waste management facilities and the regulatory authority.