| Автор | K C George |
| Автор | S A Hebbar |
| Автор | S P Kale |
| Автор | P C Kesavan |
| Дата выпуска | 1999-06-01 |
| dc.description | <p>Administration of caffeine (1,3,7-trimethylxanthine), a major component of coffee, to Swiss mice at doses of 80 or 100 mg/kg body weight 60 min prior to whole-body lethal dose of <IMG SRC="common/gamma.gif" ALT="gamma" ALIGN="TOP"/>-irradiation (7.5 Gy) resulted in the survival of 70 and 63% of animals, respectively, at the above doses in contrast to absolutely no survivors (LD-100/25 days) in the group exposed to radiation alone. Pre-treatment with a lower concentration of caffeine (50 mg/kg) did not confer any radioprotection. The protection exerted by caffeine (80 mg/kg), however, was reduced from 70 to 50% if administered 30 min prior to irradiation. The trend statistics reveal that a dose of 80 mg/kg administered 60 min before whole-body exposure to 7.5 Gy is optimal for maximal radioprotection. However, caffeine (80 mg/kg) administered within 3 min after irradiation offered no protection. While there is documentation in the literature that caffeine is an antioxidant and radioprotector against the oxic pathway of radiation damage in a wide range of cells and organisms, this is the first report demonstrating unequivocally its potent radioprotective action in terms of survival of lethally whole-body irradiated mice. </p> |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Caffeine protects mice against whole-body lethal dose of -irradiation |
| Тип | paper |
| DOI | 10.1088/0952-4746/19/2/306 |
| Electronic ISSN | 1361-6498 |
| Print ISSN | 0952-4746 |
| Журнал | Journal of Radiological Protection |
| Том | 19 |
| Первая страница | 171 |
| Последняя страница | 176 |
| Аффилиация | K C George; Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India |
| Аффилиация | S A Hebbar; Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India |
| Аффилиация | S P Kale; Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India |
| Аффилиация | P C Kesavan; Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India |
| Выпуск | 2 |
