| Автор | Zhang, Lei |
| Автор | Brett, Claire M. |
| Автор | Giacomini, Kathleen M. |
| Дата выпуска | 1998 |
| dc.description | ▪ Abstract Organic cation transporters are critical in drug absorption, targeting, and disposition. It has become increasingly clear that multiple mechanisms are involved in organic cation transport in the key tissues responsible for drug absorption and disposition: the kidney, liver, and intestine. In this review, we discuss current models of transepithelial flux of organic cations in these three tissues. Particular emphasis is placed on the more recent molecular studies that have paved the way for a more complete understanding of the physiological and pharmacological roles of the organic cation transporters. Such information is essential in predicting pharmacokinetics and pharmacodynamics and in the design and development of cationic drugs. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | ROLE OF ORGANIC CATION TRANSPORTERS IN DRUG ABSORPTION AND ELIMINATION |
| DOI | 10.1146/annurev.pharmtox.38.1.431 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 38 |
| Первая страница | 431 |
| Последняя страница | 460 |
| Аффилиация | Zhang, Lei; Departments of Biopharmaceutical Sciences and Anesthesia, University of California, San Francisco, California 94143; e-mail: kmg@itsa.ucsf.edu |
